Reaching the Unreached HCPs: From Engagement to Activation Mindset

How Alpha Sophia Helps You Profile, Prioritize, and Activate U.S. HCPs Using Claims Intelligence

In today’s hyper-targeted world, it’s no longer enough to blanket your message across channels and hope for traction. Especially in the U.S. healthcare system, many high-value healthcare professionals (HCPs) remain unreached—not because they’re uninterested, but because traditional outreach models haven’t found the right signals.

At Alpha Sophia, we empower life sciences teams to shift from a general engagement mindset to a strategic activation approach—using real-world claims data, including CPT, HCPCS, and diagnosis (ICD-10) codes, to help you identify and activate the HCPs you’re not currently reaching.

Who Are the “Unreached” HCPs?

These are HCPs treating the right patient populations but are missing from your current digital and field engagement footprint. Examples include:

• Specialists billing high volumes of procedure (CPT) or treatment (HCPCS) codes in your therapeutic area

• Physicians diagnosing relevant conditions based on ICD-10 claims

• Community-based providers not covered by your current CRM or Veeva target list

• HCPs in IDNs or ACOs that don’t engage with traditional rep channels

Step 1: Upload and Analyze Your “Unreached” List

With Alpha Sophia, the process starts in the “Analyze” tab. Simply upload a list of NPIs you’re not currently reaching—whether they’re silent in CRM, never engaged digitally, or excluded from rep call plans.

We then match these NPIs against nationwide CPT, HCPCS, and diagnosis claims to reveal:

• Volume of relevant procedures or services

• Patient mix and comorbidity clusters

• Likelihood of treating your target population

• Overlap with peer referral and influence networks

Example:

A neurology brand uploaded 2,500 NPIs of unengaged specialists. Alpha Sophia revealed that 800 of them had billed CPT codes for EEG and EMG services tied to seizure diagnostics—and had consistently diagnosed epilepsy. These HCPs were prioritized for activation campaigns.

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Step 2: Prioritize HCPs Based on Patient and Procedural Fit

Not all unreached HCPs are equal. Alpha Sophia helps you triage based on:

• CPT/HCPCS code volumes for specific procedures (e.g., infusions, diagnostics, screenings)

• Diagnosis frequency over the past 6–12 months

• Practice type (e.g., private, hospital-affiliated, FQHC)

• Geographic access deserts (e.g., rural ZIP codes underserved by field teams)

Example:

A gastroenterology product team targeting IBD used Alpha Sophia to find community GIs with frequent claims for colonoscopy (CPT 45378) and moderate-to-severe Crohn’s diagnosis codes (K50.1x). Many of these HCPs were in suburban New Jersey and eastern Pennsylvania—outside the rep team’s territory, but clearly relevant.

Step 3: Engage HCPs on Their Preferred Channels

Once you’ve found and profiled your unreached HCPs, the next step is smart, channel-aware engagement.

Alpha Sophia allows you to tag HCPs by digital affinity or engagement behavior so you can align outreach strategies:

• Email: Personalized messages tied to their actual patient claims footprint

• Field: Prioritized rep or MSL targets based on real-world relevance

• Events: Invites tailored to high-opportunity HCPs by region and diagnosis code volume

Example:

A device company targeting endocrinologists ran a reactivation campaign for HCPs billing insulin pump training CPT codes (e.g., 95249) but not engaging digitally. Based on Alpha Sophia data, they delivered case studies about diabetes care outcomes via email and set follow-up triggers for local reps. Result: 20% of HCPs booked a meeting within 30 days.

Step 4: Personalize Outreach Based on Clinical Reality

Alpha Sophia enables dynamic content creation tied to what HCPs are actually doing—whether it’s diagnostics, follow-up visits, or therapeutic services.

Key personalization tactics:

• Benchmark HCP vs. peer procedural volume

• Spotlight missed diagnosis opportunities using ICD-10 gaps

• Share localized patient trends in their ZIP3 or state

Example:

A pulmonology team used Alpha Sophia to identify HCPs diagnosing chronic cough (ICD-10 R05.3) and ordering spirometry tests (CPT 94010), but not involved in any branded touchpoints. The team sent personalized insights showing under-diagnosis of chronic lung disease vs. national benchmarks. Within 6 weeks, 34% of those HCPs clicked through to educational content.

Step 5: Track Activation—Not Just Engagement

Success isn’t about clicks or open rates—it’s about behavioral activation. That’s why Alpha Sophia helps you measure:

• Field engagement lift (MSL or rep meetings)

• Event attendance or registration uptick

• Sample requests or formulary inquiries

• Increase in relevant CPT/diagnosis activity over time

Example:

A rare disease brand tracked a 27% increase in diagnostic workups (CPT 81206 and ICD-10 E75.22) from a cohort of previously unreached pediatric neurologists within 3 months of tailored digital and field outreach informed by Alpha Sophia data.

Final Thought: From Insight to Action

Reaching the unreached isn’t about more noise—it’s about targeted activation rooted in real-world clinical behavior. With Alpha Sophia, you can:

✅ Upload and analyze your own list of NPIs

✅ Discover hidden patient volumes using CPT, HCPCS, and diagnosis claims

✅ Prioritize outreach with confidence

✅ Move HCPs from silence to activation

Ready to close the gap between potential and performance?

Let Alpha Sophia help you turn unengaged HCPs into your next growth engine.

Find any and every HCP, not just the ones looking for a job

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